Abstract
Ten flavonoids were isolated from the ethyl acetate-soluble fraction of the ethanolic extract of the seeds of Trigonella foenum-graecum and their structures were elucidated on the basis of spectroscopic methods to be 5,7,3'-trihydroxy-5'-methoxylisoflavone (1), biochanin A (2), formononetin (3), irilone (4), tricin (5), daidzein (6), calycosin (7), orientin-2''-O-p-trans-coumarate (8), vitexin-2''-O-p-trans-coumarate (9), and tricin-7-O-beta-D: -glucopyranoside (10). Compounds 1 and 8 are new flavonoids, and 8 and 9 strongly promoted 2BS cell proliferation induced by H(2)O(2).
MeSH terms
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Cell Line
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Cell Proliferation / drug effects*
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Coumaric Acids / chemistry
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Flavonoids / chemistry*
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Flavonoids / pharmacology*
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Genistein / chemistry
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Glucosides / chemistry
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Humans
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Hydrogen Peroxide / pharmacology
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Isoflavones / chemistry
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology*
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Seeds / chemistry*
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Trigonella / chemistry*
Substances
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Coumaric Acids
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Flavonoids
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Glucosides
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Isoflavones
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Plant Extracts
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irilone
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7,3'-dihydroxy-4'-methoxyisoflavone
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formononetin
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Hydrogen Peroxide
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tricin
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Genistein
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biochanin A