Freezing Polo in its sleep: targeting the inactive conformation of Polo-like kinase 1 in cancer cells

Cell Cycle. 2010 Mar 1;9(5):862. Epub 2010 Mar 1.
No abstract available

Publication types

  • News
  • Comment

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Apoptosis
  • Benzylamines / pharmacology*
  • Cell Cycle Proteins / antagonists & inhibitors
  • Cell Cycle Proteins / metabolism*
  • Cell Division
  • HeLa Cells
  • Humans
  • Polo-Like Kinase 1
  • Protein Kinase Inhibitors / pharmacology*
  • Protein Serine-Threonine Kinases / antagonists & inhibitors
  • Protein Serine-Threonine Kinases / metabolism*
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins / antagonists & inhibitors
  • Proto-Oncogene Proteins / metabolism*
  • Pyridines / pharmacology*

Substances

  • Antineoplastic Agents
  • Benzylamines
  • Cell Cycle Proteins
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins
  • Pyridines
  • SBE13 compound
  • Protein Serine-Threonine Kinases