Cholelithiasis as a cause of jaundice in the neonatal period is rare. We are going to describe a case of cholestasis with cholangitis due to calculus of choledochus. None of the causes favouring cholelithiasis described in medical studies proved to be present. The diagnosis was made through an ultrasonographic check of the upper abdomen. The case resolved spontaneously. Our case suggests a cautious attitude and careful clinical and echographic monitoring.