Abstract
There is a need for new safe, effective and short-course treatments for leishmaniasis; one strategy is to use combination chemotherapy. Polymer-drug conjugates have shown promise for the delivery of anti-leishmanial agents such as amphotericin B. In this paper, we report on the preparation and biological evaluation of polymer-drug conjugates of N-(2-hydroxypropyl)methacrylamide (HPMA), amphotericin B and alendronic acid. The combinatorial polymer-drug conjugates were effective anti-leishmanial agents in vitro and in vivo, but offered no advantage over the single poly(HPMA)-amphotericin B conjugates.
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / chemistry*
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Antiprotozoal Agents / therapeutic use*
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Biological Availability
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Chromatography, High Pressure Liquid
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Cricetinae
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Dose-Response Relationship, Drug
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Drug Therapy, Combination
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Female
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Leishmania donovani / drug effects
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Leishmaniasis, Visceral / drug therapy*
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Leishmaniasis, Visceral / parasitology
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Liver / parasitology
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Macrophages, Peritoneal / drug effects
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Macrophages, Peritoneal / parasitology
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Mesocricetus
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Methacrylates
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Mice
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Mice, Inbred BALB C
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Polymers
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Solubility
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Spectrophotometry, Ultraviolet
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Water
Substances
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Antiprotozoal Agents
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Methacrylates
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Polymers
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Water
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hydroxypropyl methacrylate