Palladium-catalyzed heck coupling reaction of aryl bromides in aqueous media using tetrahydropyrimidinium salts as carbene ligands

Molecules. 2010 Jan 28;15(2):649-59. doi: 10.3390/molecules15020649.

Abstract

An efficient and stereoselective catalytic system for the Heck cross coupling reaction using novel 1,3-dialkyl-3,4,5,6-tetrahydropyrimidinium salts (1, LHX) and Pd(OAc)2 loading has been reported. The palladium complexes derived from the salts 1a-f prepared in situ exhibit good catalytic activity in the Heck coupling reaction of aryl bromides under mild conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bromides / chemistry*
  • Catalysis
  • Chemistry, Organic / methods*
  • Ligands
  • Methane / analogs & derivatives*
  • Methane / chemistry
  • Palladium / chemistry*
  • Pyrimidines / chemical synthesis
  • Pyrimidines / chemistry*
  • Salts / chemistry*
  • Styrene / chemistry
  • Water / chemistry*

Substances

  • Bromides
  • Ligands
  • Pyrimidines
  • Salts
  • Water
  • carbene
  • Styrene
  • Palladium
  • Methane