Inhibition of trans-plasma membrane electron transport: a potential anti-leukemic strategy

Cecilia Prata; Carole Grasso; Stefano Loizzo; Francesco Vieceli Dalla Sega; Cristiana Caliceti; Laura Zambonin; Diana Fiorentini; Gabriele Hakim; Michael V Berridge; Laura Landi

doi:10.1016/j.leukres.2010.02.032

Inhibition of trans-plasma membrane electron transport: a potential anti-leukemic strategy

Leuk Res. 2010 Dec;34(12):1630-5. doi: 10.1016/j.leukres.2010.02.032. Epub 2010 Mar 24.

Authors

Cecilia Prata¹, Carole Grasso, Stefano Loizzo, Francesco Vieceli Dalla Sega, Cristiana Caliceti, Laura Zambonin, Diana Fiorentini, Gabriele Hakim, Michael V Berridge, Laura Landi

Affiliation

¹ Department of Biochemistry G. Moruzzi, University of Bologna, Bologna, Italy. cecilia.prata@unibo.it

PMID: 20334912
DOI: 10.1016/j.leukres.2010.02.032

Abstract

The recently demonstrated reliance of glycolytic cancer cells on trans-plasma membrane electron transport (tPMET) for survival raises the question of its suitability as a target for anticancer drug development. In this study, the effects of several new and known compounds on proliferation, tPMET activity and NAD(P)H intrinsic fluorescence in human myelogenous leukemic cell lines were investigated. The whole data confirm the importance of tPMET in leukemic cell survival and suggest this activity as a new potential anti-leukemic target.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Membrane / metabolism*
Drug Screening Assays, Antitumor
Electron Transport / drug effects*
Humans
Leukemia / drug therapy*
Leukemia / metabolism*
NAD / metabolism*

Substances

Antineoplastic Agents
NAD