Abstract
Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isothiocyanates promoted by silica gel are described. This reaction proceeds smoothly at 80 degrees C under metal- and solvent-free conditions, which provides an efficient and practical route for the generation of 2,4-dihydro-1H-benzo[d][1,3]thiazines. The recovered silica gel could be reused for several times.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry*
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Amines / chemistry*
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Benzene Derivatives / chemistry*
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Benzothiazoles / chemical synthesis
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Benzothiazoles / chemistry*
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Cyclization
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Isothiocyanates / chemistry*
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Models, Chemical
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Silica Gel
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Silicon Dioxide / chemistry*
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Temperature
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Thiazines / chemical synthesis*
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Thiazines / chemistry
Substances
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Alkynes
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Amines
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Benzene Derivatives
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Benzothiazoles
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Isothiocyanates
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Thiazines
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Silica Gel
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Silicon Dioxide