Single-walled carbon nanotube-based chemiresistive affinity biosensors for small molecules: ultrasensitive glucose detection

Lakshmi N Cella; Wilfred Chen; Nosang V Myung; Ashok Mulchandani

doi:10.1021/ja100503b

Single-walled carbon nanotube-based chemiresistive affinity biosensors for small molecules: ultrasensitive glucose detection

J Am Chem Soc. 2010 Apr 14;132(14):5024-6. doi: 10.1021/ja100503b.

Authors

Lakshmi N Cella¹, Wilfred Chen, Nosang V Myung, Ashok Mulchandani

Affiliation

¹ Department of Chemical and Environmental Engineering, University of California, Riverside, California 92521, USA.

Abstract

We report for the first time single-walled carbon nanotube (SWNT)-based chemiresistive affinity sensors for highly sensitive and selective detection of small and/or weakly charged or uncharged molecules using a displacement format. The detection of glucose, a small, weakly charged molecule, by displacement of plant lectin (concavalin A) bound to a polysaccharide (dextran) immobilized on SWNTs with picomolar sensitivity and selectivity over other sugars and human serum proteins is demonstrated as a proof of concept.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biosensing Techniques*
Glucose / analysis*
Molecular Weight
Nanotubes, Carbon / chemistry*
Surface Properties

Substances

Nanotubes, Carbon
Glucose

Abstract

Publication types

MeSH terms

Substances

Grants and funding