Abstract
Acortatarins A (1) and B (2), two novel spiroalkaloids with a naturally unusual morpholine motif, were isolated from the rhizome of Acorus tatarinowii. Their structures with absolute configuration were determined by spectroscopic methods, X-ray diffraction analysis, and Mosher's method. Importantly, compound 1 could significantly inhibit reactive oxygen species production in high-glucose-stimulated mesangial cells in a dose- and time-dependent manner.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acorus / chemistry*
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Animals
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Antioxidants / chemistry*
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Biological Products / chemistry*
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Mesangial Cells / drug effects
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Mesangial Cells / metabolism
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Morpholines / chemistry*
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Morpholines / isolation & purification
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Morpholines / pharmacology*
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Rats
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Reactive Oxygen Species / metabolism
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Spiro Compounds / chemistry*
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Spiro Compounds / isolation & purification
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Spiro Compounds / pharmacology*
Substances
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Alkaloids
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Antioxidants
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Biological Products
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Morpholines
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Reactive Oxygen Species
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Spiro Compounds
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acortatarin A
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acortatarin B
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morpholine