Mitochondrial DNA alterations and reduced mitochondrial function in aging

Mech Ageing Dev. 2010 Jul-Aug;131(7-8):451-62. doi: 10.1016/j.mad.2010.03.007. Epub 2010 Mar 20.

Abstract

Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Age Factors
  • Aging / genetics*
  • Aging / metabolism
  • Animals
  • DNA Damage*
  • DNA, Mitochondrial / metabolism*
  • Energy Metabolism / genetics
  • Gene Expression Regulation
  • Humans
  • Mice
  • Mitochondria / metabolism*
  • Mutation
  • Oxidative Stress
  • Reactive Oxygen Species / metabolism

Substances

  • DNA, Mitochondrial
  • Reactive Oxygen Species