Comparison of salivary cortisol and calculated free plasma cortisol during low-dose ACTH test in healthy subjects

Jana Kerlik; Adela Penesova; Miroslav Vlcek; Richard Imrich; Michael Vogeser; Zofia Radikova

doi:10.1016/j.clinbiochem.2010.03.005

Comparison of salivary cortisol and calculated free plasma cortisol during low-dose ACTH test in healthy subjects

Clin Biochem. 2010 Jun;43(9):764-7. doi: 10.1016/j.clinbiochem.2010.03.005. Epub 2010 Mar 19.

Authors

Jana Kerlik¹, Adela Penesova, Miroslav Vlcek, Richard Imrich, Michael Vogeser, Zofia Radikova

Affiliation

¹ Laboratory of Human Endocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia. jana.kerlik@savba.sk

PMID: 20307523
DOI: 10.1016/j.clinbiochem.2010.03.005

Abstract

Objectives: To compare free plasma cortisol (FPC) with salivary and calculated cortisol.

Design and methods: FPC, salivary cortisol, free cortisol index (FCI), albumin-derived free cortisol index (FCIalb), Coolen's and Dorin's cortisol were assayed during repeated low-dose ACTH test in healthy women.

Results: FPC significantly correlated with its surrogates, the most with FCIalb and salivary cortisol. FPC and salivary cortisol showed the highest method agreement.

Conclusions: FCIalb and salivary cortisol are preferred surrogates of FPC.

Publication types

Case Reports
Comparative Study
Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Adrenocorticotropic Hormone / administration & dosage
Adrenocorticotropic Hormone / pharmacology*
Adult
Female
Follicular Phase
Humans
Hydrocortisone / analysis*
Hydrocortisone / blood
Saliva / chemistry*

Substances

Adrenocorticotropic Hormone
Hydrocortisone