Abstract
According to a highly polymorphic region in the lytA gene, encoding the major autolysin of Streptococcus pneumoniae, two different families of alleles can be differentiated by PCR and restriction digestion. Here, we provide evidence that this polymorphic region arose from recombination events with homologous genes of pneumococcal temperate phages.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Bacterial Proteins / classification
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Bacterial Proteins / genetics*
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Base Sequence
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Lysogeny / genetics
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Molecular Sequence Data
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N-Acetylmuramoyl-L-alanine Amidase / genetics*
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Phylogeny
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Polymerase Chain Reaction
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Polymorphism, Genetic / genetics
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Prophages / genetics*
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Sequence Homology, Amino Acid
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Streptococcus pneumoniae / genetics*
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Streptococcus pneumoniae / virology*
Substances
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Bacterial Proteins
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N-Acetylmuramoyl-L-alanine Amidase