Abstract
A group of styrylazanaphthalenes and azanaphthalenediones were synthesized and tested for their anti-proliferative activity. Most of the compounds were obtained with the use of microwave-assisted synthesis. The lipophilicity of the compounds was measured by RP-HPLC and their anti-proliferative activity was assayed against the human SK-N-MC neuroepithelioma and HCT116 human colon carcinoma cell lines. Active compounds were also tested in clonogenity and comet assays. Several quinazolinone and styrylquinazoline analogues were found to have markedly greater anti-proliferative activity than desferoxamine and cis-platin.
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Chromatography, High Pressure Liquid
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Coloring Agents
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Drug Screening Assays, Antitumor
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Humans
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Lipids / chemistry
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Naphthalenes / chemical synthesis*
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Naphthalenes / pharmacology*
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Naphthoquinones / chemical synthesis*
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Naphthoquinones / pharmacology*
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Solubility
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Styrenes / chemical synthesis*
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Styrenes / pharmacology*
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Tetrazolium Salts
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Thiazoles
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Tumor Stem Cell Assay
Substances
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Antineoplastic Agents
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Coloring Agents
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Lipids
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Naphthalenes
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Naphthoquinones
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Styrenes
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Tetrazolium Salts
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Thiazoles
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thiazolyl blue