The THO complex as a key mRNP biogenesis factor in development and cell differentiation

Sonia Jimeno; Andrés Aguilera

doi:10.1186/jbiol217

The THO complex as a key mRNP biogenesis factor in development and cell differentiation

J Biol. 2010;9(1):6. doi: 10.1186/jbiol217. Epub 2010 Jan 28.

Authors

Sonia Jimeno¹, Andrés Aguilera

Affiliation

¹ Centro Andaluz de Biología Molecular y Medicina Regenerativa, Av. Américo Vespucio s/n, 41092 Sevilla, Spain.

Abstract

The THO complex is a key component in the co-transcriptional formation of messenger ribonucleoparticles that are competent to be exported from the nucleus, yet its precise function is unknown. A recent study in BMC Biology on the role of the THOC5 subunit in cell physiology and mouse development provides new clues to the role of the THO complex in cell differentiation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Nucleus / chemistry*
Mice
Mice, Knockout
Mutation
Nuclear Proteins / physiology*
RNA, Messenger / physiology*
Ribonucleoproteins / biosynthesis
Ribonucleoproteins / physiology*
Saccharomyces cerevisiae / metabolism
Saccharomyces cerevisiae Proteins

Substances

Nuclear Proteins
RNA, Messenger
Ribonucleoproteins
Saccharomyces cerevisiae Proteins
messenger ribonucleoprotein