Abstract
(+)-Scyphostatin (1) was synthesized via (i) construction of a side-chain 3b of > or = 98% purity in 19% yield in eleven steps featuring ZACA reaction, Negishi coupling, and HWE olefination, (ii) an asymmetric synthesis of a fully protected core 4 from 10a, and (iii) a three-step assembly of 1 in 42% yield.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemistry*
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Amides / chemical synthesis*
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Amides / chemistry
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Catalysis
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Pyrones / chemical synthesis*
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Pyrones / chemistry
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Stereoisomerism
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Zirconium / chemistry*
Substances
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Alkenes
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Amides
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Pyrones
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scyphostatin
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Zirconium