Locked nucleic acids: promising nucleic acid analogs for therapeutic applications

Chem Biodivers. 2010 Mar;7(3):536-42. doi: 10.1002/cbdv.200900343.

Abstract

Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aptamers, Nucleotide / chemistry
  • DNA / chemistry
  • DNA, Catalytic / chemistry
  • DNA, Catalytic / metabolism
  • MicroRNAs / chemistry
  • MicroRNAs / metabolism
  • Oligonucleotides / chemistry*
  • Oligonucleotides / therapeutic use
  • Oligonucleotides, Antisense / chemistry
  • RNA, Complementary / chemistry
  • RNA, Small Interfering / chemistry
  • RNA, Small Interfering / metabolism

Substances

  • Aptamers, Nucleotide
  • DNA, Catalytic
  • MicroRNAs
  • Oligonucleotides
  • Oligonucleotides, Antisense
  • RNA, Complementary
  • RNA, Small Interfering
  • locked nucleic acid
  • DNA