Eight experimental trials were carried out during 2007 and 2008 to evaluate the efficacy of different fungicides against downy mildew of lettuce (Bremia lactucae) and basil (Peronospora belbahrii) under greenhouse conditions, at temperatures ranging from 19 to 24 degrees C. The mixture fluopicolide (fungicide belonging to the + propamocarb hydrochloride (fungicide belonging to the new chemical class of acyl-picolides) was compared with metalaxyl m + copper, zoxamide + mancozeb, iprovalicarb + Cu, fenamidone + fosetyl-Al and azoxystrobin. Two treatments were carried out at 8-12 day interval on lettuce and basil. The artificial inoculation of B. lactucae on lettuce (cv Cobham Green) and P. belbahrii. on basil (cv Genovese gigante) was carried out by using 1 x 10(5) CFU/ml 24 h after the first treatment. In the presence of a medium-high disease severity, all fungicides tested in these trials were effective against downy mildew on lettuce and basil as the other fungicides already available. The importance of the availability of a number of different chemicals to control downy mildews is discussed.