Disseminated Scedosporium/Pseudallescheria infection after double-lung transplantation in patients with cystic fibrosis

J Clin Microbiol. 2010 May;48(5):1978-82. doi: 10.1128/JCM.01840-09. Epub 2010 Mar 10.

Abstract

We report a case of disseminated Scedosporium/Pseudallescheria infection due to Pseudallescheria boydii sensu stricto after lung transplantation in a patient with cystic fibrosis. Dissemination occurred under voriconazole. Despite surgery and combination therapy with voriconazole, caspofungin, and terbinafine, the patient died 8 months after transplantation. Previously reported cases are reviewed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use
  • Brain / diagnostic imaging
  • Caspofungin
  • Chemoprevention / methods
  • Cystic Fibrosis / therapy*
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • Echinocandins / therapeutic use
  • Fatal Outcome
  • Female
  • Humans
  • Lipopeptides
  • Lung Diseases, Fungal / diagnosis*
  • Lung Diseases, Fungal / drug therapy
  • Lung Diseases, Fungal / microbiology
  • Lung Diseases, Fungal / surgery
  • Lung Transplantation / adverse effects*
  • Magnetic Resonance Imaging
  • Microbial Sensitivity Tests
  • Microscopy
  • Molecular Sequence Data
  • Naphthalenes / therapeutic use
  • Pseudallescheria / classification
  • Pseudallescheria / cytology
  • Pseudallescheria / genetics
  • Pseudallescheria / isolation & purification*
  • Pyrimidines / therapeutic use
  • RNA, Fungal / genetics
  • RNA, Ribosomal, 28S / genetics
  • Radiography
  • Scedosporium / classification
  • Scedosporium / cytology
  • Scedosporium / genetics
  • Scedosporium / isolation & purification*
  • Sequence Analysis, DNA
  • Terbinafine
  • Triazoles / therapeutic use
  • Voriconazole

Substances

  • Antifungal Agents
  • DNA, Fungal
  • Echinocandins
  • Lipopeptides
  • Naphthalenes
  • Pyrimidines
  • RNA, Fungal
  • RNA, Ribosomal, 28S
  • Triazoles
  • Caspofungin
  • Terbinafine
  • Voriconazole

Associated data

  • GENBANK/GU180097
  • GENBANK/GU180098
  • GENBANK/GU180099
  • GENBANK/GU180100
  • GENBANK/GU180101
  • GENBANK/GU186103
  • GENBANK/GU186104
  • GENBANK/GU186105
  • GENBANK/GU186106
  • GENBANK/GU186107
  • GENBANK/GU192438
  • GENBANK/GU192439
  • GENBANK/GU192440
  • GENBANK/GU192441
  • GENBANK/GU192442
  • GENBANK/GU213261
  • GENBANK/GU213262
  • GENBANK/GU213263
  • GENBANK/GU213264
  • GENBANK/GU213265