NMR structure/function relationships of peptides corresponding to the C1B1 Region of PKC gamma

Protein Pept Lett. 2010 Jan;17(1):1-10. doi: 10.2174/092986610789909485.

Abstract

The region (101-112) of C1B domain in PKC gamma plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • 14-3-3 Proteins / metabolism
  • Amino Acid Sequence
  • Animals
  • Binding, Competitive
  • Cell Survival
  • Cells, Cultured
  • Gap Junctions
  • Models, Biological
  • Molecular Sequence Data
  • Mutation
  • Nuclear Magnetic Resonance, Biomolecular / methods*
  • Peptides / chemistry*
  • Peptides / genetics
  • Peptides / metabolism
  • Protein Kinase C / chemistry*
  • Protein Kinase C / genetics
  • Protein Kinase C / metabolism
  • Protein Structure, Tertiary / genetics
  • Rabbits
  • Structure-Activity Relationship

Substances

  • 14-3-3 Proteins
  • Peptides
  • protein kinase C gamma
  • Protein Kinase C