Immune reconstitution could be found in part of HIV/AIDS patients after receiving highly active anti-retroviral therapy (HAART). Its influencing factors are very complex. Many factors, such as the demographic factor, stage of HIV disease, pattern of therapy, sort of co-infections, baseline of CD; T-cell count, abnormal immune activation, related immune phenotype, and virologic factors, all could influence the immune reconstitution. In view of Chinese medline (CM) may play a positive role in this process, the clinical evidences for above-mentioned factors were summed up briefly in this paper for providing reference to the future studies on immune reconstitution with intervention of CM.