RNA-mediated regulation in bacteria: from natural to artificial systems

Efthimia Lioliou; Cédric Romilly; Pascale Romby; Pierre Fechter

doi:10.1016/j.nbt.2010.03.002

RNA-mediated regulation in bacteria: from natural to artificial systems

N Biotechnol. 2010 Jul 31;27(3):222-35. doi: 10.1016/j.nbt.2010.03.002. Epub 2010 Mar 6.

Authors

Efthimia Lioliou¹, Cédric Romilly, Pascale Romby, Pierre Fechter

Affiliation

¹ Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, 15 rue René Descartes, Strasbourg cedex, France.

PMID: 20211281
DOI: 10.1016/j.nbt.2010.03.002

Abstract

Bacteria use various means of RNA-mediated gene regulation. Regulatory RNAs include mRNA leaders that affect expression in cis or in trans, non-coding RNAs that trap regulatory proteins or interact with one or multiple target mRNAs, and RNAs that protect the bacteria against foreign and invasive DNA. The aim of this review is to outline the basic principles of bacterial RNA-mediated regulation, with a special focus on both cis-acting regulatory regions of mRNAs and antisense RNAs (asRNAs), and to give a brief overview of selected examples of RNA-based technology that have paved the way for biotechnological applications.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bacteria / genetics*
Bacteria / metabolism
Bacterial Proteins / genetics
Bacterial Proteins / metabolism
Gene Expression Regulation, Bacterial*
Nucleic Acid Conformation
RNA, Antisense / genetics
RNA, Antisense / metabolism
RNA, Bacterial / chemistry
RNA, Bacterial / genetics
RNA, Bacterial / metabolism*
Regulatory Sequences, Nucleic Acid / genetics

Substances

Bacterial Proteins
RNA, Antisense
RNA, Bacterial