Abstract
A new dihydroisocoumarin was isolated from a dichloromethane extract of Haloxylon scoparium with the aid of a functional assay with Xenopus oocytes transiently expressing GABA(A) receptors of defined subunit composition (alpha(1)beta(2)gamma(2S)). Compound 1 induced a maximum potentiation of the chloride currents by 144.6 +/- 35.3% with an EC(50) of 140.2 +/- 51.2 muM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amaranthaceae / chemistry*
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Animals
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Chloride Channels / drug effects
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Chromatography, High Pressure Liquid
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GABA Modulators / pharmacology
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Isocoumarins / chemistry
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Isocoumarins / isolation & purification*
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Isocoumarins / pharmacology*
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Molecular Structure
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Morocco
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Oocytes / metabolism
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Receptors, GABA-A / drug effects*
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Receptors, GABA-A / metabolism
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Receptors, GABA-A / physiology
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Xenopus laevis / metabolism
Substances
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(S)-4-methoxy-7-phenyl-7,8-dihydro(1,3)dioxolo(4,5-g)isochromen-5-one
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Chloride Channels
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GABA Modulators
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Isocoumarins
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Receptors, GABA-A