Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. II: Structure elucidation

J Antibiot (Tokyo). 2010 Apr;63(4):157-63. doi: 10.1038/ja.2010.10. Epub 2010 Mar 5.

Abstract

The structures of nosokomycins A, B, C and D, new anti-methicillin-resistant Staphylococcus aureus antibiotics produced by Streptomyces sp. K04-0144, were elucidated by spectroscopic studies including various NMR experiments. Nosokomycins A, B, C and D are new members of the moenomycin family consisting of an oligosaccharide moiety, a 2,3-dihydroxypropionic acid and an unusual sesterterpenoid moiety. All nosokomycins lack the cyclopentenone moiety in the oligosaccharide moiety of moenomycin A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Bombyx
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Larva
  • Molecular Conformation
  • Molecular Sequence Data
  • Nuclear Magnetic Resonance, Biomolecular
  • Oligosaccharides / chemistry*
  • Oligosaccharides / isolation & purification
  • Propionates / chemistry*
  • Propionates / isolation & purification
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Ultraviolet
  • Streptomyces / chemistry*

Substances

  • Anti-Bacterial Agents
  • Oligosaccharides
  • Propionates
  • Sesquiterpenes