Abstract
The structures of nosokomycins A, B, C and D, new anti-methicillin-resistant Staphylococcus aureus antibiotics produced by Streptomyces sp. K04-0144, were elucidated by spectroscopic studies including various NMR experiments. Nosokomycins A, B, C and D are new members of the moenomycin family consisting of an oligosaccharide moiety, a 2,3-dihydroxypropionic acid and an unusual sesterterpenoid moiety. All nosokomycins lack the cyclopentenone moiety in the oligosaccharide moiety of moenomycin A.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / isolation & purification
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Bombyx
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Carbohydrate Conformation
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Carbohydrate Sequence
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Larva
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Molecular Conformation
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Molecular Sequence Data
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Nuclear Magnetic Resonance, Biomolecular
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Oligosaccharides / chemistry*
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Oligosaccharides / isolation & purification
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Propionates / chemistry*
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Propionates / isolation & purification
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Ultraviolet
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Streptomyces / chemistry*
Substances
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Anti-Bacterial Agents
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Oligosaccharides
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Propionates
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Sesquiterpenes