Abstract
This article examines the transitions in pharmacological therapy for obesity. It reviews the current options approved by the Food and Drug Administration and several drugs approved for other indications that can be used to treat obesity as well. Because weight regulation is complex and redundant systems protect against perceived starvation, optimal treatment of obesity in individual patients will likely require different combinations of behavioral, nutritional, pharmacologic, endoscopic, and surgical therapies.
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Anti-Obesity Agents / pharmacology
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Anti-Obesity Agents / therapeutic use*
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Appetite Depressants / administration & dosage
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Appetite Depressants / pharmacology
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Appetite Depressants / therapeutic use
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Bariatric Surgery
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Benzazepines / pharmacology
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Benzazepines / therapeutic use
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Bupropion / pharmacology
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Bupropion / therapeutic use
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Cyclobutanes / administration & dosage
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Cyclobutanes / pharmacology
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Cyclobutanes / therapeutic use
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Ephedrine / pharmacology
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Ephedrine / therapeutic use
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Fenfluramine / adverse effects
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Humans
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Lactones / administration & dosage
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Lactones / pharmacology
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Lactones / therapeutic use
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Naltrexone / pharmacology
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Naltrexone / therapeutic use
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Obesity / drug therapy*
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Orlistat
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Phentermine / pharmacology
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Phentermine / therapeutic use
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Weight Gain / drug effects
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Weight Loss
Substances
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Anti-Obesity Agents
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Appetite Depressants
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Benzazepines
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Cyclobutanes
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Lactones
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Bupropion
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Fenfluramine
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Naltrexone
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lorcaserin
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Orlistat
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Phentermine
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Ephedrine
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sibutramine