Abstract
In 2007 and 2008 in Myanmar, we detected influenza viruses A (H3N2) that exhibited reduced sensitivity to both zanamivir and amantadine. These rare and naturally occurring viruses harbored a novel Q136K mutation in neuraminidase and S31N mutation in M2.
MeSH terms
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Amantadine / pharmacology*
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Antiviral Agents / pharmacology*
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Drug Resistance, Viral* / genetics
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Humans
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Influenza A Virus, H3N2 Subtype / drug effects*
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Influenza A Virus, H3N2 Subtype / genetics
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Influenza, Human / virology
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutation
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Myanmar
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Neuraminidase / genetics
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Phylogeny
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Sequence Analysis, DNA
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Viral Matrix Proteins / genetics*
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Viral Proteins / genetics
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Zanamivir / pharmacology*
Substances
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Antiviral Agents
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M2 protein, Influenza A virus
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Viral Matrix Proteins
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Viral Proteins
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Amantadine
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NA protein, influenza A virus
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Neuraminidase
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Zanamivir
Associated data
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GDB/GQ478863
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GENBANK/FJ229860
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GENBANK/FJ229893
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GENBANK/GQ478854