The aim of the study was to investigate the stability of some oral liquid formulations containing 1 mg/ml captopril.
Material and method: The oral solutions were prepared using captopril substance, keeping the formulation as simple as possible to avoid potentially undesirable excipients. Samples were stored for 39 days below 8 degrees C and at 22 +/- 3 degrees C and analysed for physical, chemical and microbiological stability.
Results: The formulations with ascorbic acid are stable for seven days either at 8 and 22 degrees C and could be prepared in hospital pharmacy as a more safely alternative to children terapy with tablets powders.