Abstract
Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1beta and IL-18. Recent studies have identified microbial and endogenous molecules as well as possible mechanisms involved in inflammasome activation.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Apoptosis / immunology
-
Bacterial Infections / immunology*
-
CARD Signaling Adaptor Proteins
-
Cytoskeletal Proteins / immunology
-
Humans
-
Inflammation / immunology
-
Inflammation / microbiology*
-
Interleukin-1beta / immunology
-
Multiprotein Complexes / immunology*
-
Mycoses / immunology*
-
Nod Signaling Adaptor Proteins / immunology
-
Signal Transduction / immunology
-
Virus Diseases / immunology*
Substances
-
CARD Signaling Adaptor Proteins
-
Cytoskeletal Proteins
-
Interleukin-1beta
-
Multiprotein Complexes
-
Nod Signaling Adaptor Proteins
-
PYCARD protein, human