Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum

Org Lett. 2010 Apr 2;12(7):1420-3. doi: 10.1021/ol902890j.

Abstract

A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and its subcellular localization in Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) is the main site of its accumulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / analysis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism*
  • Antineoplastic Agents / toxicity
  • Artemisinins / analysis*
  • Artemisinins / chemistry
  • Artemisinins / metabolism*
  • Artemisinins / toxicity
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Endoplasmic Reticulum / metabolism*
  • Fluorescence*
  • Humans
  • Molecular Conformation
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tissue Distribution

Substances

  • Antineoplastic Agents
  • Artemisinins
  • artemisinin