Abstract
We propose low-similarity P-170 peptide-based antibodies to neutralize the multidrug resistance phenomenon and, consequently, improve the treatment regimens for cancer chemotherapy. As a first step in the experimental validation of this approach, we report on the similarity analysis of the P-170 primary amino acid structure versus the human proteome and describe peptide motifs uniquely owned by the human P-170 glycoprotein.
MeSH terms
-
ATP Binding Cassette Transporter, Subfamily B
-
Amino Acid Sequence
-
Antibodies, Blocking / pharmacology*
-
Antineoplastic Agents / adverse effects
-
Antineoplastic Agents / therapeutic use*
-
Databases, Protein
-
Drug Resistance, Multiple / drug effects*
-
Drug Resistance, Neoplasm / drug effects*
-
Epitopes / genetics
-
Glycoproteins / antagonists & inhibitors
-
Glycoproteins / chemistry*
-
Glycoproteins / immunology
-
Humans
-
Molecular Sequence Data
-
Peptide Fragments / chemistry
-
Peptide Fragments / immunology
-
Peptide Fragments / pharmacology*
-
Proteome / chemistry*
Substances
-
ABCB1 protein, human
-
ATP Binding Cassette Transporter, Subfamily B
-
Antibodies, Blocking
-
Antineoplastic Agents
-
Epitopes
-
Glycoproteins
-
Peptide Fragments
-
Proteome