P-170 peptides with low similarity to the human proteome: tracing an effective and safe biological way towards effective and safe cancer chemotherapy

J Exp Ther Oncol. 2009;8(2):151-5.

Abstract

We propose low-similarity P-170 peptide-based antibodies to neutralize the multidrug resistance phenomenon and, consequently, improve the treatment regimens for cancer chemotherapy. As a first step in the experimental validation of this approach, we report on the similarity analysis of the P-170 primary amino acid structure versus the human proteome and describe peptide motifs uniquely owned by the human P-170 glycoprotein.

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B
  • Amino Acid Sequence
  • Antibodies, Blocking / pharmacology*
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use*
  • Databases, Protein
  • Drug Resistance, Multiple / drug effects*
  • Drug Resistance, Neoplasm / drug effects*
  • Epitopes / genetics
  • Glycoproteins / antagonists & inhibitors
  • Glycoproteins / chemistry*
  • Glycoproteins / immunology
  • Humans
  • Molecular Sequence Data
  • Peptide Fragments / chemistry
  • Peptide Fragments / immunology
  • Peptide Fragments / pharmacology*
  • Proteome / chemistry*

Substances

  • ABCB1 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • Antibodies, Blocking
  • Antineoplastic Agents
  • Epitopes
  • Glycoproteins
  • Peptide Fragments
  • Proteome