Abstract
Chemical investigations of the Formosan soft coral Lemnalia flava have obtained a new ylangene-type sesquiterpenoid, (1S,2S,4R,6S,7R,8S)-4alpha-formyloxy-beta-ylangene (1), along with two known sesquiterpenoids, lemnalol (2) and isolemnalol (3). Three new nardosinane-type sesquiterpenoids, designated as paralemnolins J-L (4-6), and five known sesquiterpenoids (7-11), were isolated from the other soft coral Paralemnalia thyrsoides. The structures of metabolites 1 and 4-6 were elucidated through extensive spectroscopic analysis and chemical methods. Moreover, the anti-inflammatory activity of metabolites 1-7 and 11 was evaluated in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anthozoa / metabolism
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology
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Cyclooxygenase 2 / metabolism
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Gene Expression Regulation, Enzymologic / drug effects
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Macrophages / enzymology
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Mice
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Models, Molecular
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Molecular Conformation
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Nitric Oxide Synthase Type II / antagonists & inhibitors
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Nitric Oxide Synthase Type II / metabolism
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
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Species Specificity
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Stereoisomerism
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Structure-Activity Relationship
Substances
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(1S,2S,4R,6S,7R,8S)-4alpha-formyloxy-beta-ylangene
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Anti-Inflammatory Agents
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Lipopolysaccharides
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Sesquiterpenes
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Nitric Oxide Synthase Type II
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Cyclooxygenase 2