Abstract
Thirty eight heterocyclic chalcones were synthesized by condensing formylquinolines with diverse methyl arylketones. The target compounds were characterized by spectroscopic techniques (NMR, IR, MS) and elemental analysis. The X-ray crystallographic study of (2E)-3-(2-chloro-6-methylquinolin-3-yl)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-en-1-one (1p) was also performed for the structure confirmation. The title compounds were screened for anti-microbial and antileishmanial activities. The compounds 1c-e, 1g, 1j-m, 1p, 1r-s, 2g, 2j-p, and 2r-s were found potentially active antileishmanial agents, while 1f-i, 1l, 1o-p, 2f-i, 2l, and 2o-p showed remarkable antibacterial activity. Only compounds 1g and 2g-h exhibited significant antifungal activity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Infective Agents / chemical synthesis
-
Anti-Infective Agents / chemistry
-
Anti-Infective Agents / pharmacology*
-
Antiprotozoal Agents / chemical synthesis
-
Antiprotozoal Agents / chemistry
-
Antiprotozoal Agents / pharmacology*
-
Crystallography, X-Ray
-
Dioxins / chemical synthesis
-
Dioxins / chemistry
-
Dioxins / pharmacology*
-
Escherichia coli / drug effects*
-
Leishmania major / drug effects*
-
Microbial Sensitivity Tests
-
Micrococcus luteus / drug effects*
-
Models, Molecular
-
Molecular Conformation
-
Parasitic Sensitivity Tests
-
Quinolines / chemical synthesis
-
Quinolines / chemistry
-
Quinolines / pharmacology*
-
Staphylococcus aureus / drug effects*
-
Stereoisomerism
-
Structure-Activity Relationship
Substances
-
Anti-Infective Agents
-
Antiprotozoal Agents
-
Dioxins
-
Quinolines