Relevance of the site of assisted hatching in thawed human blastocysts: a preliminary report

Hirotoshi Miyata; Hidehiko Matsubayashi; Noriko Fukutomi; Junko Matsuba; Azusa Koizumi; Tatsuhiro Tomiyama

doi:10.1016/j.fertnstert.2010.01.056

Relevance of the site of assisted hatching in thawed human blastocysts: a preliminary report

Fertil Steril. 2010 Nov;94(6):2444-7. doi: 10.1016/j.fertnstert.2010.01.056. Epub 2010 Mar 2.

Authors

Hirotoshi Miyata¹, Hidehiko Matsubayashi, Noriko Fukutomi, Junko Matsuba, Azusa Koizumi, Tatsuhiro Tomiyama

Affiliation

¹ Osaka New ART Clinic and New ART Research Center, Osaka, Japan.

PMID: 20189555
DOI: 10.1016/j.fertnstert.2010.01.056

Abstract

Preliminary data from a prospective randomized study of assisted hatching (AH) of thawed human blastocysts demonstrated that the rate of complete hatching was significantly higher for AH performed near the inner cell mass (ICM) than for AH at the side opposite to the ICM. This suggests the existence of polarity in the hatching process in human blastocysts, which requires further evaluation.

Publication types

Randomized Controlled Trial

MeSH terms

Adult
Blastocyst / cytology*
Blastocyst / physiology
Blastocyst / ultrastructure
Cryopreservation
Embryo Culture Techniques / methods*
Embryo Transfer
Female
Freezing
Humans
Infertility, Female / therapy
Male
Pilot Projects
Pregnancy
Pregnancy Rate
Reproductive Techniques, Assisted*
Zona Pellucida / physiology