Dendritic cell subsets digested: RNA sensing makes the difference!

Immunity. 2010 Feb 26;32(2):149-51. doi: 10.1016/j.immuni.2010.02.006.

Abstract

In this issue of Immunity, Luber et al. (2010) report a comprehensive quantitative proteome of in vivo mouse spleen dendritic cell (DC) subsets: a data set of encyclopedic value already revealing that DC subsets exploit different RNA sensors for virus recognition.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Cell Separation
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases / genetics
  • DEAD-box RNA Helicases / immunology
  • DEAD-box RNA Helicases / metabolism
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism*
  • Dendritic Cells / pathology
  • Flow Cytometry
  • Gene Expression Profiling
  • Host-Pathogen Interactions / immunology
  • Mice
  • Proteomics*
  • RNA, Viral / immunology*
  • Receptors, Pattern Recognition / genetics
  • Receptors, Pattern Recognition / immunology
  • Receptors, Pattern Recognition / metabolism
  • Signal Transduction / immunology
  • Virus Diseases / immunology*
  • Viruses / genetics
  • Viruses / immunology*

Substances

  • Adaptor Proteins, Signal Transducing
  • IPS-1 protein, mouse
  • RNA, Viral
  • Receptors, Pattern Recognition
  • Ddx58 protein, mouse
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases