Triterpenoids from Calophyllum inophyllum and their growth inhibitory effects on human leukemia HL-60 cells

Yan-Zhi Li; Zhan-Lin Li; Shi-Liang Yin; Guang Shi; Ming-Sheng Liu; Yong-Kui Jing; Hui-Ming Hua

doi:10.1016/j.fitote.2010.02.005

Triterpenoids from Calophyllum inophyllum and their growth inhibitory effects on human leukemia HL-60 cells

Fitoterapia. 2010 Sep;81(6):586-9. doi: 10.1016/j.fitote.2010.02.005. Epub 2010 Feb 24.

Authors

Yan-Zhi Li¹, Zhan-Lin Li, Shi-Liang Yin, Guang Shi, Ming-Sheng Liu, Yong-Kui Jing, Hui-Ming Hua

Affiliation

¹ Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China.

PMID: 20188156
DOI: 10.1016/j.fitote.2010.02.005

Abstract

A new friedelane-type triterpene (1), along with seven known triterpenoids, was isolated from the stems and leaves of Calophyllum inophyllum Linn. Their structures were established as 3beta, 23-epoxy-friedelan-28-oic acid (1), friedelin (2), epifriedelanol (3), canophyllal (4), canophyllol (5), canophyllic acid (6), 3-oxo-friedelan-28-oic acid (7), and oleanolic acid (8) by spectroscopic methods (NMR, EI-MS). The growth inhibitory effects of these triterpenoids on human leukemia HL-60 cells were determined.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Calophyllum / chemistry*
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Molecular Structure
Triterpenes / chemistry
Triterpenes / isolation & purification*

Substances

3beta,23-epoxy-friedelan-28-oic acid
Antineoplastic Agents, Phytogenic
Triterpenes