Abstract
Ten new polyhydroxysteroidal glycosides, anthenosides B-K (2-11), were isolated from the ethanol extract of the starfish Anthenea chinensis. Their structures were elucidated by extensive spectroscopic studies and chemical evidence. The unprecedented carbohydrate chain 6-O-methyl-beta-d-galactofuranosyl-(1-->3)-(6-O-methyl-beta-d-galactofuranose) was present in all the compounds except compounds 10 and 11. Compounds 5, 7, a mixture of 8 and 9, and a mixture of 10 and 11 showed inhibitory activity against human tumor K-562 and BEL-7402 cells. Furthermore, the mixture of 10 and 11 also exhibited cytotoxicity against human tumor U87MG cells and promoted tubulin polymerization.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Humans
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K562 Cells
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Starfish / chemistry*
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Steroids / chemistry
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Steroids / isolation & purification*
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Steroids / pharmacology
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Tubulin Modulators / chemistry
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Tubulin Modulators / isolation & purification*
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Tubulin Modulators / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Glycosides
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Steroids
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Tubulin Modulators