A mathematical model of the transport of basic ions (K+, Na+, Cl-) across the hepatocyte membrane has been created using the previously constructed models of active ion transport in biomembranes. The dependence of the resting potential on extracellular ion concentration has been established. Using the model, it is possible to independently calculate the resting potential at the biomembrane and the concentrations of sodium, potassium, and chlorine ions in the cell. The calculated internal concentrations of the ions are in good agreement with the corresponding experimental values.