Synthesis of 2'-N-formamido nucleosides and biological evaluation

Mikhail Abramov; Marleen Renders; Piet Herdewijn

doi:10.1080/15257770903362164

Synthesis of 2'-N-formamido nucleosides and biological evaluation

Nucleosides Nucleotides Nucleic Acids. 2009 Nov;28(11):1042-50. doi: 10.1080/15257770903362164.

Authors

Mikhail Abramov¹, Marleen Renders, Piet Herdewijn

Affiliation

¹ Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Leuven, Belgium.

PMID: 20183572
DOI: 10.1080/15257770903362164

Abstract

The 2'-N-formamide derivatives of adenosine, cytidine, and 9-beta-d-arabinofuranosyladenine were synthesized and tested (as triphosphate) for their substrate capacities for the HCV NS5B polymerase.

MeSH terms

Amides / chemistry*
Base Sequence
Formates / chemistry*
Hepacivirus / drug effects*
Hepatitis C / drug therapy*
Molecular Sequence Data
Molecular Structure
Nucleosides / chemical synthesis*
Nucleosides / chemistry
Nucleosides / pharmacology

Substances

Amides
Formates
Nucleosides
formic acid