Two new cytotoxic cardenolides from the latex of Antiaris toxicaria

J Asian Nat Prod Res. 2009 Sep;11(9):832-7. doi: 10.1080/10286020903164285.

Abstract

Two new cardenolides, toxicarioside F (1) and toxicarioside G (2), were isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Their structures were elucidated on the basis of spectral data and chemical evidence. Compounds 1 and 2 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by the MTT method.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiaris / chemistry*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Apoptosis / drug effects
  • Cardiac Glycosides / chemistry
  • Cardiac Glycosides / isolation & purification*
  • Cardiac Glycosides / pharmacology*
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology*
  • HeLa Cells
  • Humans
  • K562 Cells
  • Latex / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Cardiac Glycosides
  • Drugs, Chinese Herbal
  • Latex
  • toxicarioside F
  • toxicarioside G