Abstract
Two new cardenolides, toxicarioside F (1) and toxicarioside G (2), were isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Their structures were elucidated on the basis of spectral data and chemical evidence. Compounds 1 and 2 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by the MTT method.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiaris / chemistry*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects
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Cardiac Glycosides / chemistry
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Cardiac Glycosides / isolation & purification*
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Cardiac Glycosides / pharmacology*
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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HeLa Cells
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Humans
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K562 Cells
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Latex / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Cardiac Glycosides
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Drugs, Chinese Herbal
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Latex
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toxicarioside F
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toxicarioside G