Guaiane-type sesquiterpenes from Curcuma wenyujin and their inhibitory effects on nitric oxide production

Yan Lou; Feng Zhao; Hao He; Kai-Feng Peng; Xiao-Hua Zhou; Li-Xia Chen; Feng Qiu

doi:10.1080/10286020903042358

Guaiane-type sesquiterpenes from Curcuma wenyujin and their inhibitory effects on nitric oxide production

J Asian Nat Prod Res. 2009 Aug;11(8):737-47. doi: 10.1080/10286020903042358.

Authors

Yan Lou¹, Feng Zhao, Hao He, Kai-Feng Peng, Xiao-Hua Zhou, Li-Xia Chen, Feng Qiu

Affiliation

¹ Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.

PMID: 20183317
DOI: 10.1080/10286020903042358

Abstract

Four new guaiane-type sesquiterpenes (1S,4S,5S,10R)-zedoarondiol, zedoalactones D, E, and F (1-4), along with 10 known ones (5-14), were isolated from Curcuma wenyujin Y.H. Chen et C. Ling. The structures of these new compounds were elucidated by spectroscopic methods. The inhibitory effects of compounds 1-14 on nitric oxide production in lipopolysaccharide-activated macrophages were evaluated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Curcuma / chemistry*
Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / isolation & purification*
Drugs, Chinese Herbal / pharmacology*
Lipopolysaccharides / pharmacology
Macrophages / drug effects
Mice
Molecular Structure
Nitric Oxide / biosynthesis
Nuclear Magnetic Resonance, Biomolecular
Sesquiterpenes, Guaiane / chemistry
Sesquiterpenes, Guaiane / isolation & purification*
Sesquiterpenes, Guaiane / pharmacology*
Stereoisomerism

Substances

Drugs, Chinese Herbal
Lipopolysaccharides
Sesquiterpenes, Guaiane
Nitric Oxide