Abstract
Three new C-methylated acetogenins, (2E,6Z)-9,10-dihydroxy-4-hydroxymethyl-2,6-decadiene (1), (2E,6Z)-8,9,10-trihydroxy-4-hydroxymethyl-2,6-decadiene (2), and (2E,6Z)-9-hydroxy-4-hydroxymethyl-2,6-nonadiene (3), together with two known compounds, p-hydroxybenzyl alcohol (4) and indolyl-3-carboxylic acid (5), were isolated from endophytic fungus S20 of Cephalotaxus hainanensis Li. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (IR, UV, 1D, and 2D NMR). Compound 5 showed inhibitory effects on Staphylococcus aureus and methicillin-resistant S. aureus by the filter paper disc agar diffusion method.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetogenins / chemistry
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Acetogenins / isolation & purification*
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Acetogenins / pharmacology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Cephalotaxus / microbiology*
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China
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Fungi / chemistry
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / microbiology
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Staphylococcus aureus / drug effects
Substances
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(2E,6Z)-8,9,10-trihydroxy-4-hydroxymethyl-2,6-decadiene
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(2E,6Z)-9,10-dihydroxy-4-hydroxymethyl-2,6-decadiene
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(2E,6Z)-9-hydroxy-4-hydroxymethyl-2,6-nonadiene
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Acetogenins
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Anti-Bacterial Agents