Metabolites from endophytic fungus S20 of Cephalotaxus hainanensis

J Asian Nat Prod Res. 2009 Aug;11(8):704-9. doi: 10.1080/10286020902858846.

Abstract

Three new C-methylated acetogenins, (2E,6Z)-9,10-dihydroxy-4-hydroxymethyl-2,6-decadiene (1), (2E,6Z)-8,9,10-trihydroxy-4-hydroxymethyl-2,6-decadiene (2), and (2E,6Z)-9-hydroxy-4-hydroxymethyl-2,6-nonadiene (3), together with two known compounds, p-hydroxybenzyl alcohol (4) and indolyl-3-carboxylic acid (5), were isolated from endophytic fungus S20 of Cephalotaxus hainanensis Li. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (IR, UV, 1D, and 2D NMR). Compound 5 showed inhibitory effects on Staphylococcus aureus and methicillin-resistant S. aureus by the filter paper disc agar diffusion method.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetogenins / chemistry
  • Acetogenins / isolation & purification*
  • Acetogenins / pharmacology
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Cephalotaxus / microbiology*
  • China
  • Fungi / chemistry
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Bark / microbiology
  • Staphylococcus aureus / drug effects

Substances

  • (2E,6Z)-8,9,10-trihydroxy-4-hydroxymethyl-2,6-decadiene
  • (2E,6Z)-9,10-dihydroxy-4-hydroxymethyl-2,6-decadiene
  • (2E,6Z)-9-hydroxy-4-hydroxymethyl-2,6-nonadiene
  • Acetogenins
  • Anti-Bacterial Agents