The administration of anti-platelet agents to surgical patients with a history of coronary artery disease or peripheral vascular disease represents an everyday challenge to anaesthesiologists when epidural anaesthesia or analgesia is to be considered. Practice guidelines suggest stopping clopidogrel at least 7 days before placing an epidural catheter. Withholding anti-platelet drugs represents a great risk to many of these patients. On the other hand, withholding perioperative epidural analgesia denies the patients its benefits including faster resolution of postoperative ileus, earlier ambulation, decreased risk of thromboembolism and vascular graft thrombosis, and decreased hospital stay. The charts of 306 vascular surgical patients who received epidural analgesia without withholding clopidogrel perioperatively were reviewed for the presence of any postoperative complications related to the continued intake of clopidogrel. No postoperative neurological complications resulting from the use of epidural analgesia were found in any of these patients. The point estimate (95% confidence limits) for the risk of epidural haematoma or other complications for this study is 0 (0-1)%. No neurological complications were found as a result of placing an epidural catheter in patients actively taking clopidogrel. Owing to the small sample size, we cannot recommend the liberal use of epidural analgesia with ongoing clopidogrel administration at this time. Further prospective studies, with larger sample size, are needed in order to substantiate our findings.