There is currently no licensed vaccine for brucellosis in humans. Available animal vaccines may cause disease and are considered unsuitable for use in humans. However, the causative pathogen, Brucella, is among the most common causes of laboratory-acquired infections and is a Center for Disease Control category B select agent. Thus, human vaccines for brucellosis are required. This review highlights the considerations that are needed in the journey to develop a human vaccine, including animal models, and includes an assessment of the current status of novel vaccine candidates.
© 2010 contains British Crown copyright 2010/DSTL. Published with the permission of the Controller of Her Majesty's Stationery Office. Journal compilation © 2010 Federation of European Microbiological Societies.