Schinalactone A, a new cytotoxic triterpenoid from Schisandra sphenanthera

Org Lett. 2010 Mar 19;12(6):1208-11. doi: 10.1021/ol902974j.

Abstract

A new cytotoxic triterpenoid, schinalactone A (1), together with two new biogenetically related compounds, schinalactones B (2) and C (3), has been isolated from the roots and stems of Schisandra sphenanthera.Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant cytotoxicity against PANC-1 cell lines with IC(50) values of 5.9 and 4.1 microM, respectively. A plausible biosynthetic pathway of 1 was also postulated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Molecular Conformation
  • Plant Roots / chemistry
  • Plant Stems / chemistry
  • Schisandra / chemistry*
  • Stereoisomerism
  • Structure-Activity Relationship
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Triterpenes
  • schinalactone A
  • schinalactone B
  • schinalactone C