Reining in H(2)O(2) for safe signaling

Michel B Toledano; Anne-Gaëlle Planson; Agnès Delaunay-Moisan

doi:10.1016/j.cell.2010.02.003

Reining in H(2)O(2) for safe signaling

Cell. 2010 Feb 19;140(4):454-6. doi: 10.1016/j.cell.2010.02.003.

Authors

Michel B Toledano¹, Anne-Gaëlle Planson, Agnès Delaunay-Moisan

Affiliation

¹ DSV, IBITECS, Laboratoire Stress Oxydants et Cancer, CEA-Saclay, Gif-sur-Yvette, France. michel.toledano@cea.fr

PMID: 20178737
DOI: 10.1016/j.cell.2010.02.003

Abstract

Mammalian cells use hydrogen peroxide (H(2)O(2)) not only to kill invading pathogens, but also as a signaling modulator. Woo et al. (2010) now show that the local inactivation of a H(2)O(2)-degrading enzyme ensures that the production of this oxidant is restricted to the signaling site.

Publication types

Comment
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Hydrogen Peroxide / metabolism*
Mice
Peroxiredoxins / metabolism
Receptor Protein-Tyrosine Kinases / metabolism
Signal Transduction*

Substances

Hydrogen Peroxide
Peroxiredoxins
Receptor Protein-Tyrosine Kinases