Lin28: A microRNA regulator with a macro role

Srinivas R Viswanathan; George Q Daley

doi:10.1016/j.cell.2010.02.007

Lin28: A microRNA regulator with a macro role

Cell. 2010 Feb 19;140(4):445-9. doi: 10.1016/j.cell.2010.02.007.

Authors

Srinivas R Viswanathan¹, George Q Daley

Affiliation

¹ Children's Hospital Boston and Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and the Howard Hughes Medical Institute, MA 02115, USA.

PMID: 20178735
DOI: 10.1016/j.cell.2010.02.007

Abstract

Lin28, a highly conserved RNA-binding protein, has emerged as a modulator of the processing of the let-7 microRNA. This role for Lin28 has important implications for our mechanistic understanding of pluripotency, the timing of development, and oncogenesis.

MeSH terms

Animals
Humans
Induced Pluripotent Stem Cells / metabolism
MicroRNAs / genetics*
Neoplasms / metabolism
Protein Processing, Post-Translational*
RNA-Binding Proteins / genetics*
Stem Cells / metabolism

Substances

Lin28A protein, human
MicroRNAs
RNA-Binding Proteins
mirnlet7 microRNA, human