Recognition and treatment of genitourinary complications in paediatric Crohn's disease using Infliximab

Acta Paediatr. 2010 Jul;99(7):1042-6. doi: 10.1111/j.1651-2227.2010.01731.x. Epub 2010 Feb 23.

Abstract

Although genitourinary complications of Crohn's are well recognized, available information regarding their clinical course and management is sparse especially in the paediatric population. We report a myriad of urological complications in five paediatric cases, our experience from a tertiary paediatric urological and gastroenterological centre. All children with urological complications had severe Crohn's disease which necessitated the use of immuno-suppressants including Infliximab. Three of four children healed and closed their fistulas after treatment, although failed to avoid future surgery, albeit for other reasons.

Conclusion: We suggest Infliximab should be considered as a treatment option but in the absence of a common consensus, treatment be tailored to individual cases.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antibodies, Monoclonal / therapeutic use*
  • Child
  • Crohn Disease / complications*
  • Female
  • Female Urogenital Diseases / drug therapy*
  • Female Urogenital Diseases / etiology
  • Hospitals, Pediatric
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Infliximab
  • London
  • Male
  • Male Urogenital Diseases / drug therapy*
  • Male Urogenital Diseases / etiology
  • Severity of Illness Index
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal
  • Immunosuppressive Agents
  • Infliximab