Effects on renal excretion in rats after injection of bile extracts from some fresh-water fish

Abstract

Bile acid extracts were prepared from grass carp, bighead, common carp, milk fish and tilapia. Injection of the fish bile extracts (3.6 mg/kg, i.v.) into rats increased renal excretion of water, sodium and potassium; decreased blood pressure; and hemolyzed RBCs. The diuretic, natriuretic, hypotensive and hemolytic actions of the bile extracts were stronger in grass carp, bighead and common carp, moderate in milk fish, and weakest in tilapia.