Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions

Chem Commun (Camb). 2010 Mar 14;46(10):1685-7. doi: 10.1039/b915955j. Epub 2010 Jan 13.

Abstract

Guanine (G) rich G(4)T(4)G(4) DNA and homologous PNA strands tend to form antiparallel dimeric quadruplexes. In contrast, the same DNA strands carrying planar aromatic 5'-residues preferentially form parallel DNA quadruplex. Conformation and composition of the DNA quadruplexes can be programed by pi-pi-stacking interaction exerted by the 5'-residues.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Pairing*
  • Base Sequence
  • Circular Dichroism
  • DNA / chemistry*
  • DNA / genetics
  • G-Quadruplexes*
  • Peptide Nucleic Acids / chemistry*
  • Peptide Nucleic Acids / genetics

Substances

  • Peptide Nucleic Acids
  • DNA