Two new prenylated xanthones and a new prenylated tetrahydroxanthone from the pericarp of Garcinia mangostana

Fitoterapia. 2010 Sep;81(6):595-9. doi: 10.1016/j.fitote.2010.02.002. Epub 2010 Feb 20.

Abstract

Two new prenylated xanthones and a new prenylated tetrahydroxanthone, garcimangosxanthone A-C (1-3), along with fourteen known xanthones were isolated from the pericarp of Garcinia mangostana. Their structures were elucidated on the basis of spectroscopic data. Compounds 1 and 2 exhibited in vitro cytotoxicity against A549, LAC and A375 cell lines with IC(50) values of 5.7-24.9 microM, which were comparable to those of doxorubicin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Fruit / chemistry
  • Garcinia mangostana / chemistry*
  • Humans
  • Molecular Structure
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Xanthones / chemistry
  • Xanthones / isolation & purification*

Substances

  • Antineoplastic Agents, Phytogenic
  • Terpenes
  • Xanthones