Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1

Antivir Ther. 2010;15(1):127-9. doi: 10.3851/IMP1473.

Abstract

We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.

Publication types

  • Case Reports

MeSH terms

  • Darunavir
  • Drug Resistance, Multiple, Viral*
  • Drug Therapy, Combination
  • Female
  • Fetal Blood / chemistry
  • HIV Infections / blood
  • HIV Infections / drug therapy*
  • HIV Infections / transmission
  • HIV Protease Inhibitors / blood
  • HIV Protease Inhibitors / pharmacokinetics*
  • HIV Protease Inhibitors / therapeutic use
  • HIV-1 / drug effects*
  • HIV-1 / genetics
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical
  • Pregnancy
  • Pregnancy Complications, Infectious / blood
  • Pregnancy Complications, Infectious / drug therapy*
  • Pregnancy Complications, Infectious / virology
  • RNA, Viral / genetics
  • RNA, Viral / isolation & purification
  • Ritonavir / blood
  • Ritonavir / pharmacokinetics*
  • Ritonavir / therapeutic use
  • Sulfonamides / blood
  • Sulfonamides / pharmacokinetics*
  • Sulfonamides / therapeutic use
  • Young Adult

Substances

  • HIV Protease Inhibitors
  • RNA, Viral
  • Sulfonamides
  • Ritonavir
  • Darunavir